Apply small quantity to the affected skin 2 or 3 times daily until improvement occurs. It may then be possible to maintain improvement by applying once a day, or even less often. In the more resistant lesions such as the thickened plagues of psoriasis on elbows and knees, the effect of the preparation can be enhanced by occluding overnight the treatment area with polythene film; thereafter improvement can be maintained by regular application without occlusion.